The goal of drugTargetScreen is to implement the translational framework of genoproteomic studies for cardiovascular drug discovery. More details please refer to our manuscript.
You can install the developed version of drugTargetScreen from GitHub:
# install.packages("devtools")
devtools::install_github("yangzhao98/drugTargetScreen")To illustrate how the proposed translational framework can be used to help prioritize drug targets and accelerate the drug development process, we provided a step-by-step applied example to replicate three promising lipid-related therapeutics targets encoded by APOB, LDLR, and LPA loci on coronary artery disease, as detailed here.
Note: To run the applied example successfully, you have to edit the scripts with your own data, parameters, and physical paths.
Yang Z, Zhao J, Qi Y, Deng X, Ji ZL, Liu J. A translational framework of genoproteomic studies for cardiovascular drug discovery. npj Cardiovasc Health 1, 12 (2024). https://doi.org/10.1038/s44325-024-00015-9