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If the insert size is small enough then many reads actually overlap the sequence of their mate pairs, which provides an opportunity for merging them into a longer read length. Doing this would also prevent over count of variant allele support.
The text was updated successfully, but these errors were encountered:
May be simplified when we switch to using pysam's fetch instead of pileups (#64) since we can first group all reads at a locus by their template name and then when processing each group merge multiple reads which come from the same fragment.
If the insert size is small enough then many reads actually overlap the sequence of their mate pairs, which provides an opportunity for merging them into a longer read length. Doing this would also prevent over count of variant allele support.
The text was updated successfully, but these errors were encountered: