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# Site settings
title: Wingo Lab
description: > # this means to ignore newlines until "baseurl:"
A genetics laboratory dedicated to finding and fighting the causes of brain diseases.
baseurl: "" # the subpath of your site, e.g. /blog/
url: "http://wingolab.org" # the base hostname & protocol for your site
twitter_username: wingolab
github_username: wingolab
gaaccount: ""
# Build settings
permalink: /:year/:month/:title
paginate: 3
highligher: pygments
markdown: kramdown
theme: minima
sass:
sass_dir: _scss
exclude:
- README.md
- LICENSE
- sgeOnHgcc.md
#######################################################################################
# #
# PROJECT PAGE #
# #
#######################################################################################
projects:
- title: Shared molecular mechanisms between psychiatric and neurodegenerative conditions
description: >
There is widespread pleiotropy among human traits and the high epidemiological comorbidity among the psychiatric and neurodegenerative diseases.
In this project, we hypothesize that there are shared mechanisms among related brain traits.
Specifically, we are focused on finding shared molecular contributors to brain conditions that underlie psychological traits, psychiatric conditions, and neurodegenerative illnesses.
sub_projects:
- title: A brain multi-omic approach to identify key molecular drivers of neuropsychiatric symptoms in Alzheimer's dementia
funding: NIH, R01 AG072120
description: >
Approximately 65% of individuals with mild cognitive impairment (MCI), Alzheimer's disease (AD), or AD related dementias (ADRD) experience neuropsychiatric symptoms (NPS).
These debilitating symptoms include depression, anxiety, apathy, delusions, hallucinations, agitation, sleep disturbances and are associated with faster disease progression, greater functional impairment, higher caregiver burden, and earlier institutionalization.
Current treatments for NPS in MCI/dementia have limited efficacy but high rates of adverse side effects, including higher mortality.
In this project, we aim to gain better insight into the molecular mechanisms of NPS in MCI, dementia, or both to nominate therapeutic targets.
We are using genomic investigation of well-described cohorts, exploration of brain mRNA and protein expression, and techniques integrating genetic and brain mRNA and protein expression findings to identify putative causal drivers of these debilitating symptoms.
- title: Understanding the molecular mechanisms behind how psychological well-being and depression modify AD risk
funding: NIH, R01 AG072120
description: >
Psychological well-being (PWB) and depression are important factors that modify risk for Alzheimer's disease (AD).
Specifically, depression is associated with increased risk for AD while PWB with decreased risk for AD.
Molecular mechanisms underlying these important associations, however, are not known.
In this project, we collaborate with investigators of the Rush Memory and Aging Project to identify genomic, transcriptomic, and proteomic associations with PWB.
These findings will be examined for their relationship to dementia and age-related brain pathologies to understand the role PWB may have on dementia risk.
- title: Identifying putatively causal brain proteins in psychiatric and neurodegenerative conditions
description: >
Variation in brain protein expression likely underlies some of the reason for differences in why people develop different brain related traits.
These projects aim to use results of large-scale genome-wide association studies (GWAS) and brain protein expression to identify genes that contribute to development of particular brain diseases.
sub_projects:
- title: Identifying novel brain proteins contributing to PTSD and alcohol use disorder
funding: VA, I01 BX005686
description: >
Post-traumatic stress disorder (PTSD) and alcohol use disorder (AUD) are among the most prevalent and debilitating psychiatric disorders in Veterans, and treatments for PTSD or AUD are ineffective in many patients.
The overarching goal of this work is to identify brain proteins predisposing to PTSD, AUD, or both.
These findings are likely to illuminate novel pathophysiology and potential drug targets.
This work builds on insights into the complex genetic architecture of PTSD and AUD gained through large genome-wide association studies (GWAS), recent deep proteomic brain sequencing, and approaches that integrate information from GWAS with information about the genetic control of the human brain proteomes.
- title: Elucidating molecular mechanisms of psychological well-being
funding: VA, I01 BX003853
description: >
Psychological well-being (PWB) is a multidimensional construct that encompasses positive emotion, life satisfaction, and sense of purpose and meaning in life, and is more than the absence of negative emotional states.
Many prospective longitudinal studies have shown that PWB is associated with better mental and physical health.
In this project we will investigate molecular mechanisms that underlie individual differences in PWB using human brain protein expression data.
- title: Finding genetic and molecular the causes of Alzheimer's Disease
description: >
Alzheimer's Disease (AD) is a major health crisis and new treatment approaches are needed.
Our work seeks to understand the role of sex in AD pathogenesis and identifying new AD genetic associations.
sub_projects:
- title: Integrative genomic, transcriptomic, and proteomic analyses to investigate sex-specific differences in Alzheimer's disease
funding: NIH R01 AG075827
description: >
Women are affected by AD about twice as much as men.
Why women are disproportionately affected by AD is not well understood.
In this project, we hypothesize that there is an interaction between biological sex and brain protein expression that predisposes women to have a higher risk for AD.
This hypothesis builds on our work investigating the genetic control of gene expression in the human brain but reframes the question by examining genes with evidence for differences in expression by sex.
- title: A Proteogenomic Approach to Understanding Results of Genome-wide Association Studies of Alzheimer's Disease
funding: NIH P50 AG025688
description: >
Recent genome wide association studies (GWAS) of AD have identified many regions associated with AD.
This project explores the role of brain protein expression as a potential cause for those GWAS findings.
It focuses on the role of brain protein abundance and the role of coding variants in AD.
- title: Identifying New Genetic causes of Early-onset Alzheimer's disease
description: >
Early-onset Alzheimer's disease is a particularly aggressive form of the disease with higher heritability than typical late-onset AD and has several well-described genetic causes.
This project uses next-generation sequencing to identify new genetic causes in families and individuals with this particularly aggressive form of AD.
- title: A genetic study of a large pedigree with late-onset Alzheimer's Disease
description: >
Late-onset Alzheimer's Disease, the more common form of the disease, is due to the cumulative effect of 1,000s to 10,000s of genetic changes.
However, there still appears to be families that transmit the illness as an autosomal dominant trait.
The Emory GADRC has collected a number of very large families. We are using linkage and next-generation sequencing techniques to identify high-risk alleles in these families.
- title: "Transgenerational effects of maternal stressors: Investigating the role of infant gene expression"
funding: NIH, U01 MH115484
description: >
Several prospective, longitudinal, mother-child cohort studies have found that children exposed to maternal psychological stress, depression, or anxiety during the prenatal period have higher risk for behavioral and emotional problems later in life, including increased fearfulness, anxiety, and depression.
This projects focuses on investigating molecular mechanisms underlying this association in collaboration with investigators at University of Cape Town in South Africa and at McLean Hospital.
- title: Accelerated aging and risk for Alzheimer's disease in the Emory Healthy Brain and Emory Healthy Aging Studies
description: >
Accelerated aging occurs when a person's biological age (as estimated by epigenetic DNA modification) is greater than their chronological age.
In this project, we investigate if accelerated aging is associated with lower cognitive performance, higher rate of biomarker evidence for neurodegenerative disease, and higher genetic risk for AD.
- title: Acknowledgements
description: >
We are grateful to the many research volunteers, their families, and researchers who make our work possible.
We are indebted to our excellent collaborators.
And we thank the financial support provided by the Veterans Administration, National Institutes of Health, Emory University, The To Remember Foundation, American Psychiatric Association, and the Brain and Behavior Foundation (formerly NARSAD).
#######################################################################################
# #
# PEOPLE PAGE #
# #
#######################################################################################
lab_members:
- category: "Principal Investigators"
people:
- title: Aliza P. Wingo, M.D., M.S.
pic_name: Aliza
links:
- href: https://pubmed.ncbi.nlm.nih.gov/?term=wingo+a%3F%5Bauthor%5D+or+wingo+ap%5Bauthor%5D&sort=date
name: PubMed
- href: https://www.ncbi.nlm.nih.gov/myncbi/1l9uz9whqykkE/bibliography/public/
name: NCBI Bibliography
description: >
Dr. Wingo is an Associate Professor of Psychiatry at Emory University and board-certified psychiatrist. She is also a Graduate Faculty of the Genetics and Molecular Biology Graduate Program at Emory.
She received her medical degree and residency training at Emory University School of Medicine.
Subsequently, she completed a research fellowship, Master of Science in Clinical Research, and career development award under the mentorship of Kerry Ressler, MD, Ph.D.
Dr. Wingo studies the genetic and molecular basis of depression, PTSD, as well as of psychological resilience and well-being.
Additionally, Dr. Wingo investigates molecular mechanisms underlying the detrimental and protective effects of psychological factors on dementia risk.
Dr. Wingo has received an American Psychiatric Association/Lilly Resident Research award, American Psychiatric Association Research Fellowship award, a NARSAD Young Investigator award, a VA Career Development Award, and recently six federal grants (R01, U01, Merit) to pursue her lines of research inquiries.
- title: Thomas S. Wingo, M.D.
pic_name: Thomas
links:
- href: https://pubmed.ncbi.nlm.nih.gov/?term=wingo+ts%5Bauthor%5D+or+wingo+t%3F%5Bauthor%5D&sort=date
name: PubMed
- href: https://www.ncbi.nlm.nih.gov/myncbi/thomas.wingo.1/bibliography/public/
name: NCBI Bibliography
- href: https://scholar.google.com/citations?user=kJYqCEsAAAAJ&hl=en&oi=ao
name: Google Scholar
- href: https://github.com/wingolab/
name: GitHub
description: >
Dr. Wingo is an Associate Professor of Neurology and Human Genetics at Emory University.
His primary lab is at the Center for Neurodegenerative Disease in the Whitehead building on Emory's main campus.
He has post-doctoral training in statistical genetics, next-generation sequencing, and bioinformatics.
He is a board certified neurologist with fellowship training in cognitive neurology.
Dr. Wingo is a member of the Population Biology Evolution and Ecology Graduate Program at Emory University.
- category: "Research Staff"
people:
- pic_name: Ekaterina
description: Dr. Gerasimov earned her doctoral degree in computer science at Georgia State University. She has comprehensive experience in bioinformatics and computational genomics and algorithms. Her general research interest at GSU was designing and applying advanced algorithms and statistical tools for analysis of next-generation sequencing data related to cancer and infection diseases. Dr. Gerasimov joined the Wingo lab in 2018 as an Assistant Bioinformatics Scientist.
title: Ekaterina Gerasimov, Ph.D.
- pic_name: Dennis
description: Dennis Lin received his B.S. in Computer Science from Kennesaw State University. He joined the Wingo lab in April 2022 and assists in developing and maintaining the lab’s web applications and contributing to the development of tools for general analysis.
title: Dennis Lin, B.S.
- pic_name: Jiaqi
description: Jiaqi Liu received her master's degree in Biostatistics from George Washington University. She joined the Wingo Lab in 2019 as a Biostatistician and contribute to the quality control of proteomics data and analysis of large omics datasets.
title: Jiaqi Liu, M.S.
- pic_name: Minnie
description: Se Min (Minnie) Canon is the Wingo Lab Manager and Research Specialist Supervisor. She first joined the Wingo Lab as an Undergraduate Research Assistant in the Fall of 2012 while attending Emory College. During this time, she did a Senior Research Project on identifying genetic causes of an early-onset Alzheimer’s disease case in a family cohort from Colombia. After graduating with a B.S. in Neuroscience and Behavioral Biology from Emory University, she joined the lab full-time in 2014. She later received her M.S. in Biotechnology with a concentration in Bioinformatics from Johns Hopkins University in 2021. Her work primarily involves managing various wet lab experiments and projects while supporting dry lab components of research.
title: Se Min (Minnie) Canon, M.S.
- pic_name: Selina
description: Dr. Vattathil received her Ph.D. in Human and Molecular Genetics from The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences in Houston, Texas. Her graduate and postdoctoral work focused on development and application of sensitive and robust pipelines to characterize somatic mutations in healthy individuals. Selina has used her computational genetics background to support various projects in the Wingo Lab since spring 2020.
title: Selina Vattathil, Ph.D.
- pic_name: Yue
description: Dr. Yue Liu obtained his Ph.D from Structural and Computational Biology and Molecular Biophysics program at Baylor College of Medicine (BCM). His thesis work was in assembling whole genome sequencing data for complex genomes at the Human Genome Sequencing Center (HGSC) at BCM. He has since worked at HGSC for various projects in next generation sequencing data analysis. His current interest and focus at Wingo's lab is to combine proteomics and sequencing data for better understanding of the abundance profile of the proteins and its association to diseases.
title: Yue Liu, Ph.D.
- category: "Graduate Students"
people:
- pic_name: Charlotte
description: Tsaone Chalumbila is from Botswana. She obtained her B.S. Human Neuroscience degree from the University of Birmingham (UK) and her M.S. Molecular Neuroscience degree from the University of Bristol (UK). She is currently a Ph.D. student at the University of Cape Town, and her Ph.D. is in collaboration with Emory University (The Wingo Lab). Her Ph.D. focuses on investigating the transgenerational effects of prenatal maternal psychological distress through child gene expression profiles.
title: Tsaone Charlotte Chalumbila, M.S.
- pic_name: Mei
description: Mei Zhen is a graduate student in 8-year Clinical Medicine program from Xiangya School of Medicine, Central South University. Her work is mainly focused on the association between miRNAs and cognitive trajectory.
title: Mei Zhen, M.D.
- pic_name: Taha
description: Taha Rana is currently an MPH student, studying Genetic and Molecular Epidemiology at the Rollins School of Public Health at Emory University. He obtained his B.S. in Neuroscience from George Washington University. As an undergraduate student, he conducted community-based participatory research to elucidate rates of infectious disease, health promotion, and health equity to influence health policy for social determinants of health. Taha joined the Wingo Lab in the fall of 2021 and is currently studying how genetic liability for depression is associated with the incidence of cognitive impairment for his Master's Thesis.
title: Taha Rana B.S.
- category: "Undergraduate Students"
people:
- pic_name: Rishab
description: Rishab Bhatt is an undergraduate student majoring in Neuroscience and Behavioral Biology and minoring in Computer Science. Joining the Wingo Lab in the fall of 2019, he uses machine learning to study Purpose-in-Life in both African and European Americans using the Health and Retirement Study (HRS). Rishab has strong interests in health equity, computational, and psychiatry research.
title: Rishab Bhatt
- category: "Former Post-Doctoral Fellows"
people:
- pic_name: AlexK
description: Dr. Kotlar received his Ph.D. in Genetics at Emory University in 2018 where he was guided by Dr. Wingo in the development of online services (e.g., [https://bystro.io](https://bystro.io)) that assisted researchers in analyzing terabytes of genomic data, decreasing analysis times by an order of magnitude. He briefly joined the Wingo Lab as a postdoctoral fellow working on next-generation online proteomics services. After completing a second postdoctoral fellowship at the Broad Institute of Harvard and MIT he now works for a Biotechnology start-up in Boston, MA.
title: Alex Kotlar, Ph.D.
- pic_name: Chloe
description: Dr. Robins was a Post Doc from 2018-2020. She received her Ph.D. from the Population Biology, Ecology, and Evolution Graduate Program at Emory University. Her doctoral work used statistical genetic methods to investigate the evolutionary basis of human aging. She joined the Wingo Lab after graduation, and she worked on identifying epigenetic and proteomic changes associated with Alzheimer's Disease.
title: Chloe Robins, Ph.D.
- category: "Former Graduate Students"
people:
- pic_name: Felicia
description: Felicia Obialo is from Atlanta, GA. She obtained her undergraduate degree in psychology from Xavier University of Louisiana, her master's degree in neuroscience from Tulane University, and is currently a 4th year medical student at University of North Carolina at Chapel Hill with plans to practice holistic psychiatry.
title: Felicia Obialo, M.D.
- pic_name: Haeun
description: Dr. Kong was an M.D.,Ph.D. student in Genetics and Molecular Biology Graduate Program co-mentored by Drs. Peng Jin and Thomas Wingo. The focus of her work was to identify new genetic modifiers of Fragile X Tremor Ataxia Syndrome. She is currently a dermatology resident at Emory University School of Medicine aiming to pursue a career in academic pediatric dermatology.
title: Ha Eun Kong, M.D., Ph.D.
- pic_name: Irene
description: Huige Jiang graduated from Georgia Tech with a B.S. in Biomedical Engineering and is currently pursuing a MSPH degree in Biostatistics. She started working in the Wingo lab in May 2019. Her current project is to simulate TMT proteomics data and test the performance of 2 quality control pipelines.
title: Huige Jiang, M.S.
- pic_name: Nadia
description: Nadia Harerimana is from Kigali, Rwanda and she was a graduate student in the Genetics and Molecular Biology program at Emory University while at Wingo Lab. Her Master's Thesis focused on investigating the shared genetic and molecular risk factors that contribute to depression and AD dementia.
title: Nadia Harerimana, M.S.
- category: "Former Undergraduate Students"
people:
- pic_name: Elenaor
description: As an undergraduate student at University of Georgia, Dr. Sharp examined patterns of Inheritance among families with Early-onset Alzheimer's Disease with Dr. Thomas Wingo in the 2012 SURE program. She went on to obtain her medical and masters degree from Virginia School of Medicine and is now a pediatric resident at UPMC Children's Hospital of Pittsburgh.
title: Eleanor A. Sharp, M.D., M.S.
- pic_name: Mikolaj
description: Mikolaj Figurski was a Data Science / Software Development intern in the lab from 2018-2019 who supported the application development team while he was an undergraduate student at Emory University. He anticipates graduating in 2022 with a Computer Science B.S and an Economics B.A.
title: Mikolaj Figurski
- category: "Alumni"
people:
- description: Dr. Lori received her Ph.D. in Genetic Sciences at the University of Pisa (Italy). Her dissertation focused on identifying chromosomal damages in children exposed to Chernobyl fallout to estimate long-term effects of radiation to the genome. Dr. Lori's current research involves the role of genetic and epigenetic mechanisms in the development of stress-related disorders and social behaviors. Dr. Lori has been one of the primary genetic investigators of the Grady Trauma Project involved in molecular and bioinformatics analyses of sequence variants, GWAS and whole genome sequencing. Dr. Lori joined the Wingo lab in 2018 as a Research Associate.
title: Adriana Lori, Ph.D.
- description: Ms. Innocente was a research coordinator in 2015-2016 who led Dr. Aliza Wingo's Genome-wide Association Study of Resilience until its completion in 2016.
title: Brittney Innocente, B.A.
- description: Jacob Meigs received his B.E. in Computer Engineering from the University of South Carolina. His diverse experience extends into web development, software development, and independent web consulting. He joined the Wingo lab in March 2019 and assists in developing and maintaining the lab's web applications and contributing to the development of tools for general analysis.
title: Jacob Meigs, B.E.
- description: Leo Zhao received his B.S. in Biology and Music from Emory University. As an undergraduate student, he studied the role of PTPN21 in cell mechanical properties of hematopoietic stem cells, its role in HSCs niche retention and function, as well as its role in leukemogenesis. Leo joined the Wingo lab in 2019 as a Research Specialist.
title: Leo Zhao, B.S.
- description: Dr. Xie was a Bioinformatic Scientist from 2018-2019. He received his Master Degree in Analytics at Georgia State University and Ph.D. in Biochemistry and Molecular Biology at Wuhan University, China. His work focused on proteogenomic approaches to identifing novel genetic variants related to AD.
title: Maohua Xie, Ph.D.
- description: Ms. Armendariz Ms. Armendariz graduated from Virginia Tech with a B.S. in Biochemistry and a minor in Chemistry and Psychology. She was a research coordinator for the Wingo lab from 2016-2019. She left to work for a private company in Georgia.
title: Melissa Armendariz, B.S.
- description: Ms. Stennett was a research coordinator from 2012-2013 who led Dr. Aliza Wingo's Genome-wide Association Study of Resilience before she moved to Texas to work for a private company.
title: Stephanie Stennett, M.A.
- description: Ms. Fan was a biostatistician from 2018-2019 who led the quality control efforts of brain proteomics data and analysis of large omics datasets generated by the Wingo Lab and our collaborators. She will join the joint Biostatistics Ph.D. program of South Methodist University and University of Texas Southwestern Medical Center in the Fall of 2022.
title: Wen Fan, MS.
- description: Ms. White was a senior research technician from 2012-2017. She performed targeted capture and next-generation sequencing experiments to identify new genetic causes of Alzheimer's Disease.
title: Zoe White, B.S.