diff --git a/.gitignore b/.gitignore
index 6d3ce93..eba22ea 100644
--- a/.gitignore
+++ b/.gitignore
@@ -6,6 +6,7 @@
 **/ananse/
 anansenake.egg-info/
 build/
+config.yaml
 dask-worker-space/
 example/config.yaml
 example/outdir/
diff --git a/CHANGELOG.md b/CHANGELOG.md
index 64013d5..a4c8d3c 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -19,6 +19,7 @@ The format is based on [Keep a Changelog](http://keepachangelog.com/en/1.0.0/).
 
 ### Added
 
+- experimental p300 support
 - run differential gene expression analysis using `DESeq2` from `Seq2Science` RNA-seq output
 - run peak enrichment analysis using `gimmemotifs maelstrom` from `Seq2Science` ATAC-seq output
 - obtain nonhuman transcription factor binding motifs using `gimmemotifs motif2factors`
diff --git a/anansnake/envs/ananse.yaml b/anansnake/envs/ananse.yaml
index 63e9a6b..33242fc 100644
--- a/anansnake/envs/ananse.yaml
+++ b/anansnake/envs/ananse.yaml
@@ -5,3 +5,7 @@ channels:
   - defaults
 dependencies:
   - ananse =0.5.0
+
+  - pip
+  - pip:
+      - git+https://github.com/vanheeringen-lab/ANANSE.git@p300_2
diff --git a/anansnake/envs/gimme.yaml b/anansnake/envs/gimme.yaml
index 455a5db..3e01953 100644
--- a/anansnake/envs/gimme.yaml
+++ b/anansnake/envs/gimme.yaml
@@ -8,3 +8,7 @@ dependencies:
   - gffread
   - orthofinder
   - xgboost  # optional maelstrom dependency
+
+  - pip
+  - pip:
+      - git+https://github.com/vanheeringen-lab/gimmemotifs@report
diff --git a/anansnake/rules/ananse.smk b/anansnake/rules/ananse.smk
index ce4a170..410d0c8 100644
--- a/anansnake/rules/ananse.smk
+++ b/anansnake/rules/ananse.smk
@@ -18,6 +18,7 @@ rule binding:
         expand("{benchmark_dir}/binding_{{condition}}.txt", **config)[0]
     params:
         atac_samples=lambda wildcards: CONDITIONS[wildcards.condition]["ATAC-seq samples"],
+        enhancer_data=lambda wildcards: "-P" if config.get("enhancer_data") == "p300" else "-A",
         jaccard=config["jaccard"],
     threads: 1  # multithreading not required when using a pfmscorefile
     resources:
@@ -35,7 +36,7 @@ rule binding:
         printf "using columns: {params.atac_samples}\n\n" > {log}
 
         ananse binding \
-        -A {input.atac} \
+        {params.enhancer_data} {input.atac} \
         -c {params.atac_samples} \
         -g {input.genome} \
         -p {input.pfm} \
diff --git a/example/config.yaml b/example/config.yaml
index 69c5c99..19d2f3a 100644
--- a/example/config.yaml
+++ b/example/config.yaml
@@ -50,6 +50,7 @@ merged_technical_reps: true  # set to false if you used 'technical_replicates: "
 merged_biological_reps: true  # set to false if you used 'biological_replicates: "keep" in s2s'
 
 # ANANSE binding
+enhancer_data: ATAC  # experimental option: p300
 jaccard: 0.2  # default: 0.1
 
 # ANANSE influence
diff --git a/requirements.yaml b/requirements.yaml
index 2147e05..0df8ddd 100644
--- a/requirements.yaml
+++ b/requirements.yaml
@@ -4,4 +4,4 @@ channels:
   - bioconda
   - defaults
 dependencies:
-  - seq2science =1.2.0
+  - seq2science =1.2.1