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increased frequency of apoptosis (FYPO:0000377) #3770

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ValWood opened this issue Nov 11, 2024 · 0 comments
Open

increased frequency of apoptosis (FYPO:0000377) #3770

ValWood opened this issue Nov 11, 2024 · 0 comments

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@ValWood
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ValWood commented Nov 11, 2024

We should investigate this phenotype
increased frequency of apoptosis (FYPO:0000377)

because pombe doesn't do "apoptosis'
GO:0006915
A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. PMID:18846107 PMID:21494263

we have a taxon restriction on this GO term

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