diff --git a/cmake/CompilerHelper.cmake b/cmake/CompilerHelper.cmake
index 54adf1ce31..e50b120351 100644
--- a/cmake/CompilerHelper.cmake
+++ b/cmake/CompilerHelper.cmake
@@ -51,7 +51,7 @@ if(CMAKE_C_COMPILER_ID MATCHES "PGI" OR CMAKE_C_COMPILER_ID MATCHES "NVHPC")
     # Random123 does not play nicely with NVHPC 21.11+'s detection of ABM features, see:
     # https://github.com/BlueBrain/CoreNeuron/issues/724 and
     # https://github.com/DEShawResearch/random123/issues/6.
-    list(APPEND NRN_COMPILE_DEFS R123_USE_INTRIN_H=0)
+    list(APPEND NRN_R123_COMPILE_DEFS R123_USE_INTRIN_H=0)
   endif()
 else()
   set(NRN_HAVE_NVHPC_COMPILER OFF)
diff --git a/src/gnu/CMakeLists.txt b/src/gnu/CMakeLists.txt
index e700e6d968..19fd9382c1 100644
--- a/src/gnu/CMakeLists.txt
+++ b/src/gnu/CMakeLists.txt
@@ -19,3 +19,4 @@ add_library(
   Weibull.cpp)
 set_property(TARGET nrngnu PROPERTY POSITION_INDEPENDENT_CODE ON)
 target_include_directories(nrngnu SYSTEM PRIVATE "${PROJECT_SOURCE_DIR}/external/Random123/include")
+target_compile_definitions(nrngnu PRIVATE ${NRN_R123_COMPILE_DEFS})