The correcred beta was too big

[yu137178]

Considering the different results from MRlap and TwosampleMR, I used the IVW data from TwosanmpleMR to create a MR_results list and used Ldsc data from MRlap to create a Ldsc_results.Then I used the get_correction function from MRlap. I found the the correcred beta was too bigger.
corrected effect: 0.401 ( 0.297 ), observed effect: 0.106(0.0366)

I want to know why the corrected beta value was so bigger.And even the same GWAS data , the IVW result from MRlap aiso was bigger than TwosampleMR.

[lcpilling]

Hi,
The uncorrected association (beta=0.106, SE=0.0366, p=0.0038) is statistically significant. But the correct effect is no longer significant (beta=0.401, SE=0.297, p=0.18) so you should not read too much in to the larger main effect (as the 95% CIs will be very wide, and include the null).
Luke