TwoSampleMR::clump_data requires an active internet connection

[sjfandrews]

Hi,

In applying MRlap I ran into the issue of LD clumping using TwoSampleMR::clump_data requiring an active internet connection. When no internet connection is available this will cause MRlap to fail. This can be an issue when submitting to jobs compute cluster.

A potential solution to this is using ieugwasr::ld_clump (which clump_data calls) with the option of specifying a local plink binary and LD reference to perform clumping locally.

Thanks!

[lcpilling]

This feature has now been implemented with PR #10

You can use a local installation of Plink for LD clumping with a custom reference panel (using MR_plink and MR_bfile options)