diff --git a/.opt-prof.yml b/.opt-prof.yml
new file mode 100644
index 00000000000..35a5a5382d8
--- /dev/null
+++ b/.opt-prof.yml
@@ -0,0 +1,84 @@
+# Runs OptProf for MSBuild binaries based on an insertion build
+
+trigger: none # Prevents this pipeline from triggering on check-ins
+pr: none # don't run this on PR as well, this should only trigger off on MSBuild runs
+schedules:
+  - cron: "0 9 * * Wed,Sat"
+    displayName: Weekly OptProf Run
+    branches:
+      include:
+      - main
+    always: true
+
+resources:
+  pipelines:
+  - pipeline: ComponentBuildUnderTest
+    source: MSBuild\MSBuild # The name of the pipeline that produces the artifact
+    trigger:
+      branches:
+        - vs*
+  - pipeline: DartLab
+    project: DevDiv
+    source: DartLab
+    branch: main
+  - pipeline: DartLab.OptProf
+    source: DartLab.OptProf
+    branch: main
+  repositories:
+  - repository: DartLabTemplates
+    type: git
+    name: DartLab.Templates
+    ref: refs/heads/main
+  - repository: DartLabOptProfTemplates
+    type: git
+    name: DartLab.OptProf
+    ref: refs/heads/main
+
+stages:
+- template: \templates\stages\visual-studio\single-runsettings.yml@DartLabOptProfTemplates
+  parameters:
+    ##### Required #####
+    runSettingsURI: $(Pipeline.Workspace)\ComponentBuildUnderTest\VSSetup\Insertion\OptProf\Training.runsettings
+    visualStudioBootstrapperURI: $(VisualStudio.InstallationUnderTest.BootstrapperURL)
+    ##### Optional #####
+    name: OptProfProfilingWorkflow
+    displayName: OptProf Profiling Workflow
+    optOptimizationInputsDropName: $(OptimizationInputsDropName)
+    testLabPoolName: VS-Platform # The test lab pool to run your tests in
+    testMachineImageName: Windows-10-Enterprise-20H2
+    visualStudioSigning: Test
+    variables:
+    - name: branchName # The branch in the VS repo the bootstrapper was based on
+      value: $[replace(variables['resources.pipeline.ComponentBuildUnderTest.sourceBranch'],'refs/heads/','')]
+    - name: OptimizationInputsDropName # The naming convention of the OptimizationInputsDrop
+      value: OptimizationData/DotNet-msbuild-Trusted/$(branchName)/$(resources.pipeline.ComponentBuildUnderTest.runName)/$(Build.BuildId)/$(System.StageAttempt)
+    ##### Step Hooks #####
+    preTestMachineConfigurationStepList:
+    - download: ComponentBuildUnderTest
+      artifact: MicroBuildOutputs
+      patterns: '**\BootstrapperInfo.json'
+      displayName: Download Bootstrapper Information
+    - download: ComponentBuildUnderTest
+      artifact: VSSetup
+      patterns: '**\*.runsettings'
+      displayName: Download OptProf Information
+    - powershell: |
+        try {
+          $bootstrapperInfoJson = Get-Content -Raw -Path '$(Pipeline.Workspace)\ComponentBuildUnderTest\MicroBuildOutputs\BootstrapperInfo.json' | ConvertFrom-Json
+          $vsBranch = $bootstrapperInfoJson[0].VSBranch
+          Write-Host "VSBootstrapperBranch: $vsBranch"
+          Set-AzurePipelinesVariable 'VSBootstrapperBranch' $vsBranch
+        }        
+        catch {
+          Write-Host $_
+          Write-Error "Failed to set VSBootstrapperBranch pipeline variable"
+          throw
+        }
+      displayName: Set 'VSBootstrapperBranch' variable
+    - task: PowerShell@2
+      displayName: Set 'VisualStudio.InstallationUnderTest.BootstrapperURL' variable
+      inputs:
+        filePath: $(DartLab.Path)\Scripts\VisualStudio\Bootstrapper\Get-BootstrapperURL.ps1
+        arguments: -BootstrapperInfoJsonURI '$(Pipeline.Workspace)\ComponentBuildUnderTest\MicroBuildOutputs\BootstrapperInfo.json' -VSBranch '$(VSBootstrapperBranch)' -OutVariableName 'VisualStudio.InstallationUnderTest.BootstrapperURL'
+    preDeployAndRunTestsStepList:
+    - download: ComponentBuildUnderTest
\ No newline at end of file
diff --git a/.vsts-dotnet.yml b/.vsts-dotnet.yml
index 9d70f138dbf..910c17f8051 100644
--- a/.vsts-dotnet.yml
+++ b/.vsts-dotnet.yml
@@ -163,6 +163,7 @@ stages:
                   -task VisualStudio.BuildIbcTrainingSettings
                   /p:VisualStudioDropName=$(VisualStudio.DropName)
                   /p:BootstrapperInfoPath=$(Build.StagingDirectory)\MicroBuild\Output\BootstrapperInfo.json
+                  /p:VisualStudioIbcTrainingSettingsPath=$(Build.SourcesDirectory)\eng\config\OptProf.runsettings
       displayName: 'OptProf - Build IBC training settings'
       condition: succeeded()
 
diff --git a/eng/config/OptProf.runsettings b/eng/config/OptProf.runsettings
new file mode 100644
index 00000000000..3c5f7566a46
--- /dev/null
+++ b/eng/config/OptProf.runsettings
@@ -0,0 +1,92 @@
+<?xml version="1.0" encoding="utf-8"?>
+<RunSettings>
+  <RunConfiguration>
+    <ResultsDirectory>C:\Test\Results</ResultsDirectory>
+    <TargetPlatform>X86</TargetPlatform>
+    <MaxCpuCount>1</MaxCpuCount>
+    <BatchSize>10</BatchSize>
+    <TestSessionTimeout>21600000</TestSessionTimeout>
+    <DesignMode>False</DesignMode>
+    <InIsolation>False</InIsolation>
+    <CollectSourceInformation>False</CollectSourceInformation>
+    <DisableAppDomain>False</DisableAppDomain>
+    <DisableParallelization>False</DisableParallelization>
+    <TargetFrameworkVersion>.NETFramework,Version=v4.0</TargetFrameworkVersion>
+    <ExecutionThreadApartmentState>STA</ExecutionThreadApartmentState>
+    <TestAdaptersPaths>%SystemDrive%\Test</TestAdaptersPaths>
+    <TreatTestAdapterErrorsAsWarnings>False</TreatTestAdapterErrorsAsWarnings>
+  </RunConfiguration>
+  <SessionConfiguration>
+    <!-- Generated -->
+  </SessionConfiguration>
+  <DataCollectionRunSettings>
+    <DataCollectors>
+      <DataCollector uri="datacollector://microsoft/DevDiv/TestExtensions/ProcDumpCollector/v1" friendlyName="ProcDump Collector" enabled="True">
+        <Configuration>
+          <RootDumpDirectory>C:\Test\Dumps</RootDumpDirectory>
+          <Deployment PackageName = "Microsoft.DevDiv.TestExtensions.ProcDumpCollector" />
+        </Configuration>
+      </DataCollector>
+      <DataCollector uri="datacollector://microsoft/DevDiv/TestExtensions/LingeringProcessCollector/v1" friendlyName="Lingering Process Collector" enabled="True">
+        <Configuration>
+          <KillLingeringProcesses>true</KillLingeringProcesses>          
+          <ShutdownCommands>
+            <ShutdownCommand Process="VBCSCompiler" Command="%ProcessPath%" Arguments="-shutdown" Timeout="60000" />
+          </ShutdownCommands>
+          <LoggingBehavior>Warning</LoggingBehavior>
+          <Deployment PackageName = "Microsoft.DevDiv.TestExtensions.LingeringProcessCollector" />
+        </Configuration>
+      </DataCollector>
+      <DataCollector uri="datacollector://microsoft/DevDiv/VideoRecorder/2.0" friendlyName="Screen and Voice Recorder" enabled="True">
+        <Configuration>
+          <Deployment PackageName = "Microsoft.DevDiv.Validation.MediaRecorder" />
+        </Configuration>
+      </DataCollector>
+    </DataCollectors>
+  </DataCollectionRunSettings>
+  <InProcDataCollectionRunSettings>
+    <InProcDataCollectors>
+      <InProcDataCollector uri="datacollector://microsoft/DevDiv/TestExtensions/OptProfDataCollector/v2" assemblyQualifiedName="Microsoft.DevDiv.TestExtensions.OptProfDataCollector, Microsoft.DevDiv.TestExtensions.OptProfDataCollector, Version=2.0.0.0, Culture=neutral, PublicKeyToken=null" friendlyName="OptProf Data Collector" enabled="True" codebase="C:\Test\Extensions\Microsoft.DevDiv.TestExtensions.OptProfDataCollector\lib\net461\Microsoft.DevDiv.TestExtensions.OptProfDataCollector.dll">
+        <Configuration>
+          <WorkingDirectory>C:\OptProf</WorkingDirectory>
+          <ProfilesDirectory>C:\Profiles</ProfilesDirectory>
+          <IgnoreProfileNotGeneratedExceptions>true</IgnoreProfileNotGeneratedExceptions>
+          <Deployment PackageName="Microsoft.DevDiv.TestExtensions.OptProfDataCollector" />
+        </Configuration>
+      </InProcDataCollector>
+    </InProcDataCollectors>
+  </InProcDataCollectionRunSettings>
+  <TestRunParameters />
+  <LoggerRunSettings>
+    <Loggers />
+  </LoggerRunSettings>
+  <VisualStudioConfiguration>
+    <!-- MSBuild-OptProf specific VS configuration element -->
+    <InstallationUnderTest>
+      <Components All="false">
+        <Include ID="Microsoft.VisualStudio.Component.VC.CLI.Support" />
+        <Include ID="Microsoft.VisualStudio.Component.Windows81SDK" />
+        <Include ID="Microsoft.VisualStudio.ComponentGroup.UWP.VC" />
+        <Include ID="Microsoft.VisualStudio.Component.VC.ATLMFC" />
+        <Include ID="Microsoft.VisualStudio.Component.Windows10SDK.15063.Desktop" />
+        <Include ID="Microsoft.VisualStudio.Component.Windows10SDK.16299" />
+        <Include ID="Microsoft.VisualStudio.Component.Windows10SDK.16299.UWP" />
+        <Include ID="Microsoft.Net.ComponentGroup.4.7.2.DeveloperTools" />
+        <Exclude ID="Component.Incredibuild" />
+        <Exclude ID="Component.JavaJDK" />
+        <Exclude ID="Microsoft.VisualStudio.Component.AspNet45" />
+      </Components>
+      <Workloads All="false" IncludeComponents="Required,Recommended">
+        <Include ID="Microsoft.VisualStudio.Workload.CoreEditor" IncludeComponents="Required" />
+        <Include ID="Microsoft.VisualStudio.Workload.ManagedDesktop" IncludeComponents="Required" />
+        <Include ID="Microsoft.VisualStudio.Workload.NativeCrossPlat" IncludeComponents="Required" />
+        <Include ID="Microsoft.VisualStudio.Workload.NativeDesktop" IncludeComponents="Required" />
+        <Include ID="Microsoft.VisualStudio.Workload.NetWeb" IncludeComponents="Required" />
+        <Include ID="Microsoft.VisualStudio.Workload.Office" IncludeComponents="Required" />
+        <Include ID="Microsoft.VisualStudio.Workload.Universal" IncludeComponents="Required" />
+        <Include ID="Microsoft.VisualStudio.Workload.VisualStudioExtension" IncludeComponents="Required" />
+        <Include ID="Microsoft.VisualStudio.Workload.Webcrossplat" IncludeComponents="Required" />
+      </Workloads>
+    </InstallationUnderTest>
+  </VisualStudioConfiguration>
+</RunSettings>
\ No newline at end of file