diff --git a/ci/conda_env_python.txt b/ci/conda_env_python.txt
index 8be410973e..6f6194d80b 100644
--- a/ci/conda_env_python.txt
+++ b/ci/conda_env_python.txt
@@ -23,7 +23,9 @@ pandas
 pyarrow-all
 pyright
 pytest
-setuptools
+# TODO(https://github.com/apache/arrow-adbc/issues/2176): pin for now because
+# gobject-introspection uses a deprecated/removed API
+setuptools <74
 
 # For integration testing
 polars
diff --git a/ci/scripts/python_wheel_unix_build.sh b/ci/scripts/python_wheel_unix_build.sh
index 48cb456978..96691bbae2 100755
--- a/ci/scripts/python_wheel_unix_build.sh
+++ b/ci/scripts/python_wheel_unix_build.sh
@@ -87,7 +87,9 @@ check_visibility $ADBC_SNOWFLAKE_LIBRARY
 
 # https://github.com/pypa/pip/issues/7555
 # Get the latest pip so we have in-tree-build by default
-python -m pip install --upgrade pip auditwheel cibuildwheel delocate setuptools wheel
+# https://github.com/apache/arrow-adbc/issues/2163
+# Pin cibuildwheel for now
+python -m pip install --upgrade pip auditwheel 'cibuildwheel<2.21' delocate setuptools wheel
 
 # Build with Cython debug info
 export ADBC_BUILD_TYPE="debug"