diff --git a/Kernel/Bus/USB/Drivers/HID/MouseDriver.cpp b/Kernel/Bus/USB/Drivers/HID/MouseDriver.cpp
index 2ec950a848c1df..63152e7b62e6df 100644
--- a/Kernel/Bus/USB/Drivers/HID/MouseDriver.cpp
+++ b/Kernel/Bus/USB/Drivers/HID/MouseDriver.cpp
@@ -60,11 +60,8 @@ ErrorOr<void> MouseDriver::initialize_device(USB::Device& device, USBInterface c
 {
     if (interface.endpoints().size() != 1)
         return ENOTSUP;
-    auto const& configuration = interface.configuration();
     // FIXME: Should we check other configurations?
-    TRY(device.control_transfer(
-        USB_REQUEST_RECIPIENT_DEVICE | USB_REQUEST_TYPE_STANDARD | USB_REQUEST_TRANSFER_DIRECTION_HOST_TO_DEVICE,
-        USB_REQUEST_SET_CONFIGURATION, configuration.configuration_id(), 0, 0, nullptr));
+    TRY(device.set_configuration_and_interface(interface));
 
     auto const& endpoint_descriptor = interface.endpoints()[0];
     auto interrupt_in_pipe = TRY(USB::InterruptInPipe::create(device.controller(), device, endpoint_descriptor.endpoint_address & 0xf, endpoint_descriptor.max_packet_size, 10));
diff --git a/Kernel/Bus/USB/Drivers/MassStorage/MassStorageDriver.cpp b/Kernel/Bus/USB/Drivers/MassStorage/MassStorageDriver.cpp
index 5ceab96d6119e8..5bddf93638f634 100644
--- a/Kernel/Bus/USB/Drivers/MassStorage/MassStorageDriver.cpp
+++ b/Kernel/Bus/USB/Drivers/MassStorage/MassStorageDriver.cpp
@@ -84,14 +84,11 @@ ErrorOr<void> MassStorageDriver::probe(USB::Device& device)
 ErrorOr<void> MassStorageDriver::initialise_bulk_only_device(USB::Device& device, USBInterface const& interface)
 {
     auto const& descriptor = interface.descriptor();
-    auto const& configuration = interface.configuration();
 
     if (descriptor.interface_sub_class_code != to_underlying(MassStorage::SubclassCode::SCSI_transparent))
         return ENOTSUP;
 
-    TRY(device.control_transfer(
-        USB_REQUEST_RECIPIENT_DEVICE | USB_REQUEST_TYPE_STANDARD | USB_REQUEST_TRANSFER_DIRECTION_HOST_TO_DEVICE,
-        USB_REQUEST_SET_CONFIGURATION, configuration.configuration_id(), 0, 0, nullptr));
+    TRY(device.set_configuration_and_interface(interface));
 
     u8 max_luns;
     TRY(device.control_transfer(
@@ -151,9 +148,7 @@ ErrorOr<void> MassStorageDriver::initialise_uas_device(USB::Device& device, USBI
     if (descriptor.interface_sub_class_code != to_underlying(MassStorage::SubclassCode::SCSI_transparent))
         return ENOTSUP;
 
-    TRY(device.control_transfer(
-        USB_REQUEST_RECIPIENT_DEVICE | USB_REQUEST_TYPE_STANDARD | USB_REQUEST_TRANSFER_DIRECTION_HOST_TO_DEVICE,
-        USB_REQUEST_SET_CONFIGURATION, configuration.configuration_id(), 0, 0, nullptr));
+    TRY(device.set_configuration_and_interface(interface));
 
     Optional<u8> command_pipe_endpoint_number;
     u16 command_max_packet_size;
diff --git a/Kernel/Bus/USB/USBDevice.cpp b/Kernel/Bus/USB/USBDevice.cpp
index 05b626f397cd36..2551dcb21c9f99 100644
--- a/Kernel/Bus/USB/USBDevice.cpp
+++ b/Kernel/Bus/USB/USBDevice.cpp
@@ -97,4 +97,37 @@ ErrorOr<size_t> Device::control_transfer(u8 request_type, u8 request, u16 value,
     return TRY(m_default_pipe->submit_control_transfer(request_type, request, value, index, length, data));
 }
 
+ErrorOr<void> Device::set_configuration(USBConfiguration const& configuration)
+{
+    if (m_was_configured.was_set() && m_current_configuration != configuration.configuration_id())
+        return EALREADY;
+
+    if (!m_was_configured.was_set()) {
+        m_was_configured.set();
+        m_current_configuration = configuration.configuration_id();
+
+        TRY(control_transfer(USB_REQUEST_TRANSFER_DIRECTION_HOST_TO_DEVICE | USB_REQUEST_TYPE_STANDARD | USB_REQUEST_RECIPIENT_DEVICE, USB_REQUEST_SET_CONFIGURATION,
+            m_current_configuration, 0, 0, nullptr));
+
+        // FIXME: On xHCI we should set up the all endpoints for the configuration here
+        //        Currently we set them up on the first transfer, which works good enough for now
+    }
+
+    return {};
+}
+
+ErrorOr<void> Device::set_configuration_and_interface(USBInterface const& interface)
+{
+    auto const& configuration = interface.configuration();
+    TRY(set_configuration(configuration));
+
+    // FIXME: When we use the default alternate_setting of interface/the current alternate setting, we don't need to SET_INTERFACE it
+    //        but that gets a bit difficult to track
+    TRY(control_transfer(USB_REQUEST_TRANSFER_DIRECTION_HOST_TO_DEVICE | USB_REQUEST_TYPE_STANDARD | USB_REQUEST_RECIPIENT_INTERFACE, USB_REQUEST_SET_INTERFACE,
+        interface.descriptor().alternate_setting, interface.descriptor().interface_id, 0, nullptr));
+    // FIXME: As in activate_configuration, we should set up changed endpoints on xHCI here
+
+    return {};
+}
+
 }
diff --git a/Kernel/Bus/USB/USBDevice.h b/Kernel/Bus/USB/USBDevice.h
index 5715e75c2984a2..014de85262bcfb 100644
--- a/Kernel/Bus/USB/USBDevice.h
+++ b/Kernel/Bus/USB/USBDevice.h
@@ -8,6 +8,7 @@
 
 #include <AK/Badge.h>
 #include <AK/OwnPtr.h>
+#include <AK/SetOnce.h>
 #include <AK/Types.h>
 #include <AK/Vector.h>
 #include <Kernel/Bus/USB/Drivers/USBDriver.h>
@@ -76,6 +77,8 @@ class Device : public AtomicRefCounted<Device> {
         m_driver = nullptr;
     }
 
+    ErrorOr<void> set_configuration_and_interface(USBInterface const& interface);
+
     SpinlockProtected<RefPtr<SysFSUSBDeviceInformation>, LockRank::None>& sysfs_device_info_node(Badge<USB::Hub>) { return m_sysfs_device_info_node; }
 
     template<DerivedFrom<USBController> Controller>
@@ -105,6 +108,7 @@ class Device : public AtomicRefCounted<Device> {
 
 protected:
     void set_default_pipe(NonnullOwnPtr<ControlPipe> pipe);
+    ErrorOr<void> set_configuration(USBConfiguration const& configuration);
 
     u8 m_device_port { 0 };     // What port is this device attached to. NOTE: This is 1-based.
     DeviceSpeed m_device_speed; // What speed is this device running at
@@ -121,6 +125,12 @@ class Device : public AtomicRefCounted<Device> {
     Hub const* m_hub { nullptr };
     OwnPtr<ControlPipe> m_default_pipe; // Default communication pipe (endpoint0) used during enumeration
 
+    // The current configuration is behind a SetOnce, this is the easiest way to
+    // guarantee that when a driver is attached, another driver cannot choose a different configuration
+    // using a different interface in the same configuration is fine, though
+    SetOnce m_was_configured;
+    u8 m_current_configuration { 0 };
+
     LockRefPtr<Driver> m_driver;
 
 private:
diff --git a/Kernel/Bus/USB/USBHub.cpp b/Kernel/Bus/USB/USBHub.cpp
index 61796d4cf95023..eb5916739ccd5b 100644
--- a/Kernel/Bus/USB/USBHub.cpp
+++ b/Kernel/Bus/USB/USBHub.cpp
@@ -78,7 +78,7 @@ ErrorOr<void> Hub::enumerate_and_power_on_hub()
             return EINVAL;
 
         // FIXME: Which configuration should we choose if there is more than one?
-        TRY(control_transfer(USB_REQUEST_TRANSFER_DIRECTION_HOST_TO_DEVICE | USB_REQUEST_TYPE_STANDARD | USB_REQUEST_RECIPIENT_DEVICE, USB_REQUEST_SET_CONFIGURATION, m_configurations[0].configuration_id(), 0, 0, nullptr));
+        TRY(set_configuration(m_configurations[0]));
     }
 
     USBHubDescriptor descriptor {};
diff --git a/Kernel/Bus/USB/USBRequest.h b/Kernel/Bus/USB/USBRequest.h
index 09c73f2b891b25..e22aff3405125f 100644
--- a/Kernel/Bus/USB/USBRequest.h
+++ b/Kernel/Bus/USB/USBRequest.h
@@ -41,6 +41,7 @@ static constexpr u8 USB_REQUEST_GET_DESCRIPTOR = 0x06;
 static constexpr u8 USB_REQUEST_SET_DESCRIPTOR = 0x07;
 static constexpr u8 USB_REQUEST_GET_CONFIGURATION = 0x08;
 static constexpr u8 USB_REQUEST_SET_CONFIGURATION = 0x09;
+static constexpr u8 USB_REQUEST_SET_INTERFACE = 0x0B;
 
 // Table 9-6
 static constexpr u16 USB_FEATURE_DEVICE_REMOTE_WAKEUP = 1;